In vivo imaging of newt lens regeneration with OCT

Weihao Chen; Georgios Tsissios; Anthony Sallese; B. Smucker; A.-T. Nguyen; J. Chen; Katia Del Rio-Tsonis; Hui Wang

doi:10.1117/12.2578861

5 March 2021 In vivo imaging of newt lens regeneration with OCT

Weihao Chen, Georgios Tsissios, Anthony Sallese, B. Smucker, A.-T. Nguyen, J. Chen, Katia Del Rio-Tsonis, Hui Wang

Proceedings Volume 11647, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX; 1164706 (2021) https://doi.org/10.1117/12.2578861
Event: SPIE BiOS, 2021, Online Only

Abstract

Newts have the exceptional capability of regenerating the lens through their lifetime. The transparency of the anterior chamber makes OCT an idea imaging technology to track the entire process of the lens regeneration in vivo without interruptions. We demonstrated, for the first time, that OCT can capture not only essential morphological changes similar to the changes observed in histology but some fine structures, like zonular fibers, which are not visible in histology. Our initial results warrant the future research of tailoring OCT for dynamically imaging the lens regeneration in newts.

Conference Presentation

Citation Download Citation

Weihao Chen, Georgios Tsissios, Anthony Sallese, B. Smucker, A.-T. Nguyen, J. Chen, Katia Del Rio-Tsonis, and Hui Wang "In vivo imaging of newt lens regeneration with OCT", Proc. SPIE 11647, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 1164706 (5 March 2021); https://doi.org/10.1117/12.2578861

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