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5 March 2021 High speed wide-field mid-infrared photothermal imaging by a single-pixel pump-probe camera
Jiaze Yin, Lu Lan, Yeran Bai, Celalettin Yurdakul, Haonan Zong, Ji-Xin Cheng
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Proceedings Volume 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021; 116560J (2021) https://doi.org/10.1117/12.2578471
Event: SPIE BiOS, 2021, Online Only
Abstract
Mid-infrared photothermal (MIP) microscopy overcomes the resolution and huge water background limits in conventional mid-infrared imaging by probing the mid-infrared absorption induced photothermal effect. However, to detect the subtle MIP signal, large probe power and lock-in detection are needed, which limit the imaging speed of current MIP systems. To overcome this limitation, we develop a single-pixel pump-probe camera that leverages the large well-depth capacity of photodiode to achieve high-speed wide-field MIP imaging. With compressive sensing applied, close to video-rate MIP imaging can be achieved, offering a powerful label-free chemical imaging tool to scrutinize the complex biological systems.
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Jiaze Yin, Lu Lan, Yeran Bai, Celalettin Yurdakul, Haonan Zong, and Ji-Xin Cheng "High speed wide-field mid-infrared photothermal imaging by a single-pixel pump-probe camera", Proc. SPIE 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, 116560J (5 March 2021); https://doi.org/10.1117/12.2578471
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KEYWORDS
Cameras
Mid-IR
Photons
Absorption
Imaging systems
Spatial resolution
Microscopy
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