Rapid fabrication of customizable microneedle molds using digital light processing 3D printing methods

Xiumei Wu; Qi Sun; Wen Qiao; Jinghao Cui; Linsen Chen

doi:10.1117/12.2599425

18 June 2021 Rapid fabrication of customizable microneedle molds using digital light processing 3D printing methods

Xiumei Wu, Qi Sun, Wen Qiao, Jinghao Cui, Linsen Chen

Proceedings Volume 11850, First Optics Frontier Conference; 118500N (2021) https://doi.org/10.1117/12.2599425
Event: First Optics Frontier Conference, 2021, Hangzhou, China

Abstract

The microneedle array (MNA) is a painless, minimally invasive device composed of micrometer-sized and submillimeterheight needles, which is used to deliver drugs or extract signals. In this paper, we can use digital light processing (DLP) 3D printing technology to simply fabricate sharp MNAs (tip radius<6 μm) and good straightness (coefficient of determination R²>0.996) with adjustable size, then PDMS molds can be obtained by replicating MNAs through the soft imprinting process. Further, we proposed a UV imprinting method to produce microneedle molds rapidly and massively, by casting photosensitive resin in PDMS mold to transfer the MNAs microstructure. Based on the dissolvable MNAs fabricated by PDMS molds, we also conducted a skin penetration study to verify the functional capabilities of the MNAs in biomedicine.

Citation Download Citation

Xiumei Wu, Qi Sun, Wen Qiao, Jinghao Cui, and Linsen Chen "Rapid fabrication of customizable microneedle molds using digital light processing 3D printing methods", Proc. SPIE 11850, First Optics Frontier Conference, 118500N (18 June 2021); https://doi.org/10.1117/12.2599425

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