Mapping corneal stiffness with compressional optical coherence elastography

Manmohan Singh; Achuth Nair; Salavat R. Aglyamov; Kirill V. Larin

doi:10.1117/12.2610012

4 March 2022 Mapping corneal stiffness with compressional optical coherence elastography

Manmohan Singh, Achuth Nair, Salavat R. Aglyamov, Kirill V. Larin

Proceedings Volume 11941, Ophthalmic Technologies XXXII; 1194106 (2022) https://doi.org/10.1117/12.2610012
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Currently available clinical devices cannot provide localized maps of corneal stiffness. We present a phase-sensitive method of compressional optical coherence elastography (OCE) for mapping corneal stiffness. In situ measurements showed that the strain, ε, slightly decreased as a function of IOP and CXL significantly decreased the strain (P<0.001). The change in pressure in the eye-globe, ΔIOP, was also measured during compression. We quantified the elasticity, E, of the cornea by E=ΔIOP/ε. In contrast to the strain, there was a significant effect of the baseline IOP on the stiffness (P<0.001). After CXL, there was a ~85% increase in stiffness, which was significant (P<0.001). In addition to the whole sample CXL, partial CXL was performed where only one half of the cornea was treated. The strain in the untreated region was significantly greater (P=0.030) than the strain in the CXL region, and the elasticity was significantly greater in the CXL region (P=0.030). Next, in vivo measurements were performed in an anesthetized rabbit. The strain decreased by ~75% after CXL, which was significant (P<0.001). Partial CXL was performed on another animal, where only half the cornea was treated. The strain in the untreated region was significantly less (P<0.001) than the strain in the CXL region. Our results show the capability of compression-based OCE to measure changes in corneal biomechanical properties in 4 different scenarios (in situ traditional CXL, in situ partial CXL, in vivo traditional CXL, in vivo partial CXL).

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Manmohan Singh, Achuth Nair, Salavat R. Aglyamov, and Kirill V. Larin "Mapping corneal stiffness with compressional optical coherence elastography", Proc. SPIE 11941, Ophthalmic Technologies XXXII, 1194106 (4 March 2022); https://doi.org/10.1117/12.2610012

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KEYWORDS

Cornea

In vivo imaging

Elastography

Optical coherence tomography

Coherence (optics)

In situ metrology

Image compression

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