First handheld adaptive optics optical coherence tomography probe for in vivo imaging of photoreceptors

Kristen Hagan; Jongwan Park; Theodore DuBose; Somayyeh Soltanian-Zadeh; Gar Waterman; Al-Hafeez Dhalla; Anthony N. Kuo; Ryan P. McNabb; Joseph A. Izatt; Sina Farsiu

doi:10.1117/12.2609182

7 March 2022 First handheld adaptive optics optical coherence tomography probe for in vivo imaging of photoreceptors

Kristen Hagan, Jongwan Park, Theodore DuBose, Somayyeh Soltanian-Zadeh, Gar Waterman, Al-Hafeez Dhalla, Anthony N. Kuo, Ryan P. McNabb, Joseph A. Izatt, Sina Farsiu

Author Affiliations +

Proceedings Volume 11941, Ophthalmic Technologies XXXII; 119410A (2022) https://doi.org/10.1117/12.2609182
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The incorporation of adaptive optics (AO) technology into ophthalmic imaging systems has enhanced the understanding of retinal structure and function and the progression of various retinal diseases in adults by allowing for the dynamic correction of ocular and/or system aberrations. However, the in vivo visualization of important human retinal microanatomy, including cone photoreceptors, has been largely limited to fully cooperative subjects who are able to fixate and/or sit upright for extended imaging sessions in large tabletop AO systems. Previously, we developed the first handheld AO scanning laser ophthalmoscope capable of 2-D imaging of cone photoreceptors in supine adults and infants. In this work, we present the design and fabrication of the first handheld AO optical coherence tomography (HAOOCT) probe capable of collecting high-resolution volumetric images of the human retina. We designed custom optomechanics to build a spectral domain OCT system with a compact form factor of 22 cm × 18 cm × 5.2 cm and a total weight of 630 grams. The OCT imaging channel has a theoretical lateral resolution of 2.26 μm over a 1.0° × 1.0° field of view and an axial resolution of 4.01 μm. Stabilized imaging of healthy human adult volunteers revealed the 3-D photoreceptor structure and retinal pigment epithelium cells. HAOOCT was then deployed in handheld operation to image photoreceptors in upright and recumbent adults, indicating its potential to extend AO-OCT to previously excluded patient populations.

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Kristen Hagan, Jongwan Park, Theodore DuBose, Somayyeh Soltanian-Zadeh, Gar Waterman, Al-Hafeez Dhalla, Anthony N. Kuo, Ryan P. McNabb, Joseph A. Izatt, and Sina Farsiu "First handheld adaptive optics optical coherence tomography probe for in vivo imaging of photoreceptors", Proc. SPIE 11941, Ophthalmic Technologies XXXII, 119410A (7 March 2022); https://doi.org/10.1117/12.2609182

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KEYWORDS

Adaptive optics optical coherence tomography

Adaptive optics

Imaging systems

Optical coherence tomography

Cones

Image resolution

Spectroscopy

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