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Peripheral arterial disease (PAD) is a condition affecting a large population globally. It is important to identify and treat PAD at an early stage. In this work, we demonstrate the potential of an LED-based photoacoustic and ultrasound imaging system (AcousticX) in PAD diagnosis and treatment monitoring. We used AcousticX to image micro-vasculature networks in palm and foot of a human volunteer. Also, we performed human volunteer imaging experiments to evaluate the efficacy of 3D LED-based photoacoustic and ultrasound imaging in assessing the constriction of microvasculature in response to cold exposure and to study the impact of occlusion in peripheral microvasculature.
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