Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom

Sachin S. Shankar; Giavanna L. Jadick; Eric A. Hoffman; Jarron Atha; Jessica C. Sieren; Ehsan Samei; Ehsan Abadi

doi:10.1117/12.2613212

4 April 2022 Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom

Sachin S. Shankar, Giavanna L. Jadick, Eric A. Hoffman, Jarron Atha, Jessica C. Sieren, Ehsan Samei, Ehsan Abadi

Proceedings Volume 12031, Medical Imaging 2022: Physics of Medical Imaging; 120313R (2022) https://doi.org/10.1117/12.2613212
Event: SPIE Medical Imaging, 2022, San Diego, California, United States

Abstract

Traditional methods of quantitative analysis of CT images typically involve working with patient data, which is often expensive and limited in terms of ground truth. To counter these restrictions, quantitative assessments can instead be made through Virtual Imaging Trials (VITs) which simulate the CT imaging process. This study sought to validate DukeSim (a scanner-specific CT simulator) utilizing clinically relevant biomarkers for a customized anthropomorphic chest phantom. The physical phantom was imaged utilizing two commercial CT scanners (Siemens Somatom Force and Definition Flash) with varying imaging parameters. A computational version of the phantom was simulated utilizing DukeSim for each corresponding real acquisition. Biomarkers were computed and compared between the real and virtually acquired CT images to assess the validity of DukeSim. The simulated images closely matched the real images both qualitatively and quantitatively, with the average biomarker percent difference of 3.84% (range 0.19% to 18.27%). Results showed that DukeSim is reasonably well validated across various patient imaging conditions and scanners, which indicates the utility of DukeSim for further VIT studies where real patient data may not be feasible.

Citation Download Citation

Sachin S. Shankar, Giavanna L. Jadick, Eric A. Hoffman, Jarron Atha, Jessica C. Sieren, Ehsan Samei, and Ehsan Abadi "Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom", Proc. SPIE 12031, Medical Imaging 2022: Physics of Medical Imaging, 120313R (4 April 2022); https://doi.org/10.1117/12.2613212

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