Patient-specific scatter-corrected digital chest tomosynthesis in human subjects

Christina R. Inscoe; Alex J. Billingsley; Connor Puett; Otto Zhou; Jianping Lu; Yueh Lee

doi:10.1117/12.2611585

4 April 2022 Patient-specific scatter-corrected digital chest tomosynthesis in human subjects

Christina R. Inscoe, Alex J. Billingsley, Connor Puett, Otto Zhou, Jianping Lu, Yueh Lee

Proceedings Volume 12031, Medical Imaging 2022: Physics of Medical Imaging; 120313X (2022) https://doi.org/10.1117/12.2611585
Event: SPIE Medical Imaging, 2022, San Diego, California, United States

Conference Poster

Abstract

Purpose: Digital chest tomosynthesis is an attractive alternative to computed tomography (CT) for some clinical tasks but lacks the sensitivity for detection of small lung nodules due to scattered radiation. Conventional scatter mitigation techniques are not ideal. The purpose of this study was to provide an update on a human imaging study in patients with lung lesions incorporating an alternative scatter correction method. Method: Human subjects with known lung lesions were imaged with an experimental stationary digital chest tomosynthesis (s-DCT) system. A customized primary sampling device (PSD) was used to collect sparse primary beam samples prior to the normal scan. A primary sampling scatter correction (PSSC) algorithm was used to compute scatter and correct projections prior to reconstruction. Reconstruction image quality was evaluated in both scatter-corrected and uncorrected images and compared to clinical CT images by a board-certified radiologist. Results: Scatter corrected reconstruction slice images were found to exhibit improved conspicuity of a ground glass opacity in one example case. Pulmonary vasculature was also enhanced in a subject with high body mass index. These example cases are shown with quantitative evaluation. Reconstruction slice images with scatter correction exhibit greater uniformity in histogram distribution, allowing visualization of a larger range of anatomy at any window and level than their corresponding uncorrected counterparts. Conclusions: A low-dose, patient-specific scatter correction has been demonstrated in thirty-eight subjects in a human imaging study. The PSSC technique was found to enhance visualization and improve overall reconstruction image quality. A comprehensive reader study will determine clinical efficacy.

Citation Download Citation

Christina R. Inscoe, Alex J. Billingsley, Connor Puett, Otto Zhou, Jianping Lu, and Yueh Lee "Patient-specific scatter-corrected digital chest tomosynthesis in human subjects", Proc. SPIE 12031, Medical Imaging 2022: Physics of Medical Imaging, 120313X (4 April 2022); https://doi.org/10.1117/12.2611585

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