4D printed programmable shape memory left atrial appendage occlusion device

Cheng Lin; Liwu Liu; Yanju Liu; Jinsong Leng

doi:10.1117/12.2612464

20 April 2022 4D printed programmable shape memory left atrial appendage occlusion device

Cheng Lin, Liwu Liu, Yanju Liu, Jinsong Leng

Proceedings Volume 12041, Bioinspiration, Biomimetics, and Bioreplication XII; 120410E (2022) https://doi.org/10.1117/12.2612464
Event: SPIE Smart Structures + Nondestructive Evaluation, 2022, Long Beach, California, United States

Abstract

Programmable shape memory left atrial appendage (LAA) occlusion devices were explored to address the problem of wear, perforation, and other serious complications associated with Nitinol-based LAA occluders. The developed LAA devices were designed based on the optimized biomimetic network. LAA devices were manufactured by 4D printing, which endowed them with customized and transformable configurations. The LAA device exhibited outstanding durable mechanical performance and favorable biocompatibility. Besides, the shape recovery process verified that the dynamic and controllable 4D transformation of the LAA device was accessible. The LAA device can be deployed in swine heart, which showed the developed LAA device was feasible for LAA occlusion.

Conference Presentation

Citation Download Citation

Cheng Lin, Liwu Liu, Yanju Liu, and Jinsong Leng "4D printed programmable shape memory left atrial appendage occlusion device", Proc. SPIE 12041, Bioinspiration, Biomimetics, and Bioreplication XII, 120410E (20 April 2022); https://doi.org/10.1117/12.2612464

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