Reproducing traumatic brain injury in vitro with dielectric elastomer actuators

Samuel Rosset; Yi-Han Wu; Sahan Jayatissa; Thomas Park; Michael Dragunow; Iain A. Anderson; Vickie Shim

doi:10.1117/12.2613823

20 April 2022 Reproducing traumatic brain injury in vitro with dielectric elastomer actuators

Samuel Rosset, Yi-Han Wu, Sahan Jayatissa, Thomas Park, Michael Dragunow, Iain A. Anderson, Vickie Shim

Proceedings Volume 12042, Electroactive Polymer Actuators and Devices (EAPAD) XXIV; 1204203 (2022) https://doi.org/10.1117/12.2613823
Event: SPIE Smart Structures + Nondestructive Evaluation, 2022, Long Beach, California, United States

Abstract

Human brain cells are being traumatized using a dielectric elastomer actuator (DEA) cell injury device (CID). The DEAs on the CID share the same membrane as plated human pericytes, delivering an abrupt 20% strain to the cell culture thus producing an insult similar to traumatic brain injury (TBI). In this first phase of the study, we have subjected the pericytes to 50 stretching cycles at 1 Hz. 24 hours after injury, a quantitative real-time polymerase chain reaction has shown a twofold gene change for c-jun, a known inflammation marker. The CID provides a platform for the advancement of TBI pharmacology.

Conference Presentation

Citation Download Citation

Samuel Rosset, Yi-Han Wu, Sahan Jayatissa, Thomas Park, Michael Dragunow, Iain A. Anderson, and Vickie Shim "Reproducing traumatic brain injury in vitro with dielectric elastomer actuators", Proc. SPIE 12042, Electroactive Polymer Actuators and Devices (EAPAD) XXIV, 1204203 (20 April 2022); https://doi.org/10.1117/12.2613823

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