Poppy-seeding synapses within astrocytic domains: the role of synaptic spatial patterns in the astrocyte-neuron communication

Andrey Yu. Verisokin; Artem V. Kirsanov; Darya V. Verveyko; Dmitry E. Postnov; Alexey R. Brazhe

doi:10.1117/12.2626037

29 April 2022 Poppy-seeding synapses within astrocytic domains: the role of synaptic spatial patterns in the astrocyte-neuron communication

Andrey Yu. Verisokin, Artem V. Kirsanov, Darya V. Verveyko, Dmitry E. Postnov, Alexey R. Brazhe

Author Affiliations +

Proceedings Volume 12194, Computational Biophysics and Nanobiophotonics; 121940A (2022) https://doi.org/10.1117/12.2626037
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

We study the effect of introducing localized synapses on the astrocyte calcium activity. Instead of homogeneous excitation we include in the model well-defined synapses as sources of glutamate. Synaptic density was scaled according to the astrocyte morphology, in particular, surface-volume ratio in accordance with experimental data. Unlike uniform excitation model, where the calcium activity was dependent only on the astrocyte morphology, different localization of synapses causes the change in baseline calcium distribution. Localization of synapses leads to the decrease of baseline calcium levels in the peripheral regions of the astrocyte, while the dynamics of thick branches and soma does not change significantly. Introduction of synapses also affects the distribution of baseline calcium levels based on AVF parameter. Supposedly, this indicates the emergence of “microdomains” - regions of the astrocyte with the highest average activity.

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Andrey Yu. Verisokin, Artem V. Kirsanov, Darya V. Verveyko, Dmitry E. Postnov, and Alexey R. Brazhe "Poppy-seeding synapses within astrocytic domains: the role of synaptic spatial patterns in the astrocyte-neuron communication", Proc. SPIE 12194, Computational Biophysics and Nanobiophotonics, 121940A (29 April 2022); https://doi.org/10.1117/12.2626037

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