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17 March 2023 Integrated Raman spectroscopy and optical coherence tomography system for characterizing otitis media
Guillermo L. Monroy, Sean T. Fitzgerald, Andrea Locke, Jungeun Won, Darold R. Spillman Jr., Alexander Ho, Farzana R. Zaki, Honggu Choi, Eric J. Chaney, Jay A. Werkhaven, Kevin M. Mason, Anita Mahadevan-Jansen, Stephen A. Boppart
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Proceedings Volume 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023; 1235404 (2023) https://doi.org/10.1117/12.2648504
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Otitis media (OM) is a common disease of the middle ear, with 80% of children experiencing an infection before age three. Diagnostic methods rely on interpretation of symptoms from an otoscope, which help physicians visualize the eardrum. To provide precise structural and biochemical information, a prototype non-contact multimodal Raman spectroscopy (RS) and optical coherence tomography (OCT) system and handheld probe were created. Observation of in vitro physiologically-relevant ear models and comparison to in vivo scans from pediatric subjects presenting with OM detail application-specific development. Design challenges for clinical use, including maximum permissible exposure and physical size constraints, are presented.
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Guillermo L. Monroy, Sean T. Fitzgerald, Andrea Locke, Jungeun Won, Darold R. Spillman Jr., Alexander Ho, Farzana R. Zaki, Honggu Choi, Eric J. Chaney, Jay A. Werkhaven, Kevin M. Mason, Anita Mahadevan-Jansen, and Stephen A. Boppart "Integrated Raman spectroscopy and optical coherence tomography system for characterizing otitis media", Proc. SPIE 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023, 1235404 (17 March 2023); https://doi.org/10.1117/12.2648504
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KEYWORDS
Optical coherence tomography
Ear
Raman spectroscopy
Remote sensing
Bone
Diagnostics
Human subjects
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