Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics

Samuel S. Streeter; Gabrielle S. Ray; Logan M. Bateman; Kendra A. Hebert; Fallon E. Bushee; Scott W. Rodi; I. Leah Gitajn; Jaimo Ahn; Sunil Singhal; Niels D. Martin; Nicholas M. Bernthal; Christopher Lee; William T. Obremskey; Jonathan G. Shoenecker; Jonathan Thomas Elliott; Eric R. Henderson

doi:10.1117/12.2648408

14 March 2023 Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics

Samuel S. Streeter, Gabrielle S. Ray, Logan M. Bateman, Kendra A. Hebert, Fallon E. Bushee, Scott W. Rodi, I. Leah Gitajn, Jaimo Ahn, Sunil Singhal, Niels D. Martin, Nicholas M. Bernthal, Christopher Lee, William T. Obremskey, Jonathan G. Shoenecker, Jonathan Thomas Elliott, Eric R. Henderson

Author Affiliations +

Proceedings Volume 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; 123610B (2023) https://doi.org/10.1117/12.2648408
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Necrotizing soft-tissue infections (NSTIs) are aggressive and deadly. Immediate surgical debridement is standard-ofcare, but patients often present with non-specific symptoms, thereby delaying treatment. Because NSTIs cause microvascular thrombosis, we hypothesized that perfusion imaging using indocyanine green (ICG) would show diminished fluorescence signal in NSTI-affected tissues, particularly compared to non-necrotizing, superficial infections. Through a first-in-kind clinical study, we performed first-pass ICG fluorescence perfusion imaging of patients with suspected NSTIs. Early results support our hypothesis that ICG signal voids occur in NSTI-affected tissues and that dynamic contrast-enhanced fluorescence parameters reveal tissue kinetics that may be related to disease progression and extent.

Conference Presentation

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Samuel S. Streeter, Gabrielle S. Ray, Logan M. Bateman, Kendra A. Hebert, Fallon E. Bushee, Scott W. Rodi, I. Leah Gitajn, Jaimo Ahn, Sunil Singhal, Niels D. Martin, Nicholas M. Bernthal, Christopher Lee, William T. Obremskey, Jonathan G. Shoenecker, Jonathan Thomas Elliott, and Eric R. Henderson "Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics", Proc. SPIE 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, 123610B (14 March 2023); https://doi.org/10.1117/12.2648408

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