Sensitivity of cerebral blood flow and oxygenation to high-intracranial pressure

Sule Karagulleoglu Kunduraci; Mamadou Diop

doi:10.1117/12.2667567

7 March 2023 Sensitivity of cerebral blood flow and oxygenation to high-intracranial pressure

Sule Karagulleoglu Kunduraci, Mamadou Diop

Proceedings Volume 12376, Optical Tomography and Spectroscopy of Tissue XV; 123760J (2023) https://doi.org/10.1117/12.2667567
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Intraventricular hemorrhage (IVH) is a common occurrence in preterm infants born with very low birth weights, often leading to hydrocephalus. Hydrocephalus is an abnormal accumulation of cerebral spinal fluid (CSF) in the brain that can cause high intracranial pressure (ICP) and subsequent brain injuries. Unfortunately, current neuromonitoring techniques, such as ultrasonography, can only detect injuries that have already occurred. This emphasizes the need for tools that can identify indicators of brain insult prior to the injury. This study aimed to investigate whether cerebral blood flow (CBF) and oxygenation are sensitive to elevated ICP. Experiments were conducted on five newborn piglets, comprised by an experimental (n = 3) and a control group (n = 2). ICP was increased in the experimental group by continuous infusion of saline into the lumbar CSF region. CBF, deoxy- and oxy-hemoglobin (Hb and HbO₂) were continuously measured, starting 10 min before infusion and throughout the saline infusion, using a hybrid optical device that combines continuous-wave hyperspectral near infrared spectroscopy (h-NIRS) and diffuse correlation spectroscopy (DCS). Changes in CBF, Hb, and HbO₂ were computed using methods reported in our previous works. The results revealed that when ICP increases, Hb increases while HbO₂ and CBF decrease. Notably, there was a strong positive correlation between Hb and ICP and a negative correlation between HbO₂, CBF, and ICP (p<0.05). These findings suggest that CBF, Hb, and HbO₂ are sensitive to increased ICP and could be used to detect hydrocephalus-induced high ICP.

Conference Presentation

Citation Download Citation

Sule Karagulleoglu Kunduraci and Mamadou Diop "Sensitivity of cerebral blood flow and oxygenation to high-intracranial pressure", Proc. SPIE 12376, Optical Tomography and Spectroscopy of Tissue XV, 123760J (7 March 2023); https://doi.org/10.1117/12.2667567

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