A tissue-mimicking phantom with flexible optical properties for studying photoacoustic response of nanoparticles

M. S. Savinov; G. V. Tikhonowski; P. V. Shakhov; A. V. Kabashin; A. A. Popov

doi:10.1117/12.2651986

15 March 2023 A tissue-mimicking phantom with flexible optical properties for studying photoacoustic response of nanoparticles

M. S. Savinov, G. V. Tikhonowski, P. V. Shakhov, A. V. Kabashin, A. A. Popov

Author Affiliations +

Proceedings Volume 12410, Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications 2023; 1241007 (2023) https://doi.org/10.1117/12.2651986
Event: SPIE LASE, 2023, San Francisco, California, United States

Abstract

Photoacoustic imaging (PAI) is a rapidly growing imaging modality, which combines high contrast of optical absorption with deep penetration depth of ultrasound. When combined with endogenous contrast agents based on light-absorbing nanoparticles (NPs), PAI can visualize various biological processes and tissues. Here, we describe a simple experimental setup based on a tissue-mimicking phantom with flexible optical properties for studying photoacoustic (PA) response of NPs. Our approach is based on a polyacrylamide gel phantom with independently variable optical absorption and scattering. The phantom allows one to model and study PA response of contrast agents with diverse spatial distributions and concentrations. To demonstrate high potential of the developed experimental setup, we prepared a phantom with optical properties matching human prostate tissue and performed a PAI of laser-synthesized titanium nitride (TiN) NPs, distributed in a disk-shaped area, located 10 mm under the phantom surface. We believe that our approach will contribute the successful development of clinical PAI with NPs-based contrast agents.

Conference Presentation

Citation Download Citation

M. S. Savinov, G. V. Tikhonowski, P. V. Shakhov, A. V. Kabashin, and A. A. Popov "A tissue-mimicking phantom with flexible optical properties for studying photoacoustic response of nanoparticles", Proc. SPIE 12410, Nanoscale and Quantum Materials: From Synthesis and Laser Processing to Applications 2023, 1241007 (15 March 2023); https://doi.org/10.1117/12.2651986

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