Lung nodule false positive reduction using a central attention convolutional neural network on imbalanced data

Kexin Hao; Annan Cai; XingYu Feng; Ling Ma; Jingwen Zhu; Murong Wang; Yun Zhang; Baowei Fei

doi:10.1117/12.2654216

3 April 2023 Lung nodule false positive reduction using a central attention convolutional neural network on imbalanced data

Kexin Hao, Annan Cai, XingYu Feng, Ling Ma, Jingwen Zhu, Murong Wang, Yun Zhang, Baowei Fei

Author Affiliations +

Proceedings Volume 12466, Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling; 124661X (2023) https://doi.org/10.1117/12.2654216
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Conference Poster

Abstract

Computer-aided detection systems for lung nodules play an important role in the early diagnosis and treatment process. False positive reduction is a significant component in pulmonary nodule detection. To address the visual similarities between nodules and false positives in CT images and the problem of two-class imbalanced learning, we propose a Central Attention Convolutional Neural Network on Imbalanced Data (CACNNID) to distinguish nodules from a large number of false positive candidates. To solve the imbalanced data problem, we consider density distribution, data augmentation, noise reduction, and balanced sampling for making the network well-learned. During the network training, we design the model to pay high attention to the central information and minimize the influence of irrelevant edge information for extracting the discriminant features. The proposed model has been evaluated on the public dataset LUNA16 and achieved a mean sensitivity of 92.64%, specificity of 98.71%, accuracy of 98.69%, and AUC of 95.67%. The experimental results indicate that our model can achieve satisfactory performance in false positive reduction.

Citation Download Citation

Kexin Hao, Annan Cai, XingYu Feng, Ling Ma, Jingwen Zhu, Murong Wang, Yun Zhang, and Baowei Fei "Lung nodule false positive reduction using a central attention convolutional neural network on imbalanced data", Proc. SPIE 12466, Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling, 124661X (3 April 2023); https://doi.org/10.1117/12.2654216

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