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11 August 2023 Control of the viability of three-dimensional cultured skins by photobiomodulation
Yasuyuki Tsunoi, Hiromi Miyazaki, Satoko Kawauchi, Daizoh Saitoh, Mitsuru Akashi, Shunichi Sato
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Proceedings Volume 12627, Translational Biophotonics: Diagnostics and Therapeutics III; 1262724 (2023) https://doi.org/10.1117/12.2668239
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany
Abstract
Three-dimensional (3D) cultured skin with vascular networks is a useful skin substitute that enables rapid perfusion after grafting. However, the efficiency of the medium supply to thick cultured skin is limited, resulting in a reduction in viability. In this study, we applied photobiomodulation (PBM) to control the viability of 3D skins during cultivation. We compared the effects of PBM with illumination by a light-emitting diode (LED) array at four different peak wavelengths (440 nm, 523 nm, 658 nm and 823 nm); PBM was applied once during cultivation and the viability of the 3D skins was evaluated. The results showed that PBM with 823-nm light significantly improved the viability of the skins, while PBM with other wavelengths was not effective. Based on this result, we applied PBM at 823 nm every 24 hours during cultivation, and we found that the viability of the 3D skins with daily PBM was significantly higher than that with single PBM.
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Yasuyuki Tsunoi, Hiromi Miyazaki, Satoko Kawauchi, Daizoh Saitoh, Mitsuru Akashi, and Shunichi Sato "Control of the viability of three-dimensional cultured skins by photobiomodulation", Proc. SPIE 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 1262724 (11 August 2023); https://doi.org/10.1117/12.2668239
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KEYWORDS
Skin
Light emitting diodes
Tissues
Defense and security
3D modeling
Injuries
Medical research
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