Optimal fluorescence imaging of atherosclerotic human tissue

Carolyn M.C. Davenport; Andrew L. Alexander; Arthur F. Gmitro

doi:10.1117/12.44013

1 May 1991 Optimal fluorescence imaging of atherosclerotic human tissue

Carolyn M.C. Davenport, Andrew L. Alexander, Arthur F. Gmitro

Proceedings Volume 1425, Diagnostic and Therapeutic Cardiovascular Interventions; (1991) https://doi.org/10.1117/12.44013
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Multispectral imaging was investigated as a technique to exploit the spatial and spectral information available in the diagnosis of atherosclerosis. A diagnostic system is proposed that could provide direct viewing of a standard endoscopic or a total-fluorescence image. In addition, multiple spectral-feature images, each associated with a separate, narrow spectral band, could be obtained and processed to produce an optimized contrast image. In this study, a 'white-light' image and a total-fluorescence image were obtained. In addition, a three- dimensional, multispectral data set was generated, and two methods of utilizing this data were explored: (1) a per-pixel ratio of fluorescence intensities, and (2) an optimized superposition of the spectral-feature images. Fluorescence imaging is found to provide a rich data set possessing great potential for improving the detection and characterization of atheromatous disease.

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Carolyn M.C. Davenport, Andrew L. Alexander, and Arthur F. Gmitro "Optimal fluorescence imaging of atherosclerotic human tissue", Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); https://doi.org/10.1117/12.44013

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KEYWORDS

Tissues

Luminescence

Calibration

Image processing

Diagnostics and therapeutics

Imaging systems

Projection systems

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