Optical imaging of cortical activity in the living brain

Eugene H. Ratzlaff; Amiram Grinvald

doi:10.1117/12.50462

1 December 1991 Optical imaging of cortical activity in the living brain

Eugene H. Ratzlaff, Amiram Grinvald

Proceedings Volume 1439, International Conference on Scientific Optical Imaging; (1991) https://doi.org/10.1117/12.50462
Event: International Conference on Scientific Optical Imaging, 1990, Georgetown, Cayman Islands

Abstract

Recent advances in two optical imaging techniques are helping scientists develop a better understanding of the development, organization and function of the cortex for sensory information processing and higher brain functions. These new clues to a better understanding of the brain are obtained as the collective activity of million of neurons is imaged simultaneously, rather than recording the individual activity of single neurons using classical electrophysiological techniques. In the first method, voltage sensitive dyes are used to image the flow of information from one cortical site to the next in real time. The second method is based on monitoring intrinsic changes in the optical properties of active brain tissue, permitting high resolution imaging of the functional architecture of cortex. These developments have only been realized as newer optical and imaging technologies are being adopted in this rapidly expanding field.

Citation Download Citation

Eugene H. Ratzlaff and Amiram Grinvald "Optical imaging of cortical activity in the living brain", Proc. SPIE 1439, International Conference on Scientific Optical Imaging, (1 December 1991); https://doi.org/10.1117/12.50462

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available