Clinical optical dose measurement for PDT: invasive and noninvasive techniques

Roland Bays; L. Winterhalter; H. Funakubo; Philippe Monnier; Jean-Francois Savary; Georges A. Wagnieres; Daniel Braichotte; Andre Chatelain; Hubert van den Bergh; Lars Othar Svaasand; C. W. Burckhardt

doi:10.1117/12.48223

1 November 1991 Clinical optical dose measurement for PDT: invasive and noninvasive techniques

Roland Bays, L. Winterhalter, H. Funakubo, Philippe Monnier, Jean-Francois Savary, Georges A. Wagnieres, Daniel Braichotte, Andre Chatelain, Hubert van den Bergh, Lars Othar Svaasand, C. W. Burckhardt

Author Affiliations +

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48223
Event: MedTech '91, 1991, Berlin, Germany

Abstract

Two methods for clinical optical light dosimetry are developed. In the first method, which is invasive, a fluorescent probe attached to an optical fiber is inserted by means of a thin hypodermic needle and measures light transmitted through the cheek as a function of the penetration depth. In the second noninvasive method, the diffusely reflected light intensity, from a small illuminated spot on the surface of the tissue to be investigated, is measured as a function of the radial distance along the surface. Preliminary results with both methods are presented. Simulations of the second measurements, which allow for a simplified extraction procedure of the relevant optical data from such measurements, are also shown.

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Roland Bays, L. Winterhalter, H. Funakubo, Philippe Monnier, Jean-Francois Savary, Georges A. Wagnieres, Daniel Braichotte, Andre Chatelain, Hubert van den Bergh, Lars Othar Svaasand, and C. W. Burckhardt "Clinical optical dose measurement for PDT: invasive and noninvasive techniques", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48223

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