Infrared spectroscopic characterization of human white matter, grey matter, and multiple sclerosis lesions

Lin-P'ing Choo; Michael Jackson; William C. Halliday; Henry H. Mantsch

doi:10.1117/12.166686

31 January 1994 Infrared spectroscopic characterization of human white matter, grey matter, and multiple sclerosis lesions

Lin-P'ing Choo, Michael Jackson, William C. Halliday, Henry H. Mantsch

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Proceedings Volume 2089, 9th International Conference on Fourier Transform Spectroscopy; (1994) https://doi.org/10.1117/12.166686
Event: Fourier Transform Spectroscopy: Ninth International Conference, 1993, Calgary, Canada

Abstract

FT-IR spectroscopy has been used to characterize white matter, grey matter, and multiple sclerosis (MS) plaques from human central nervous system (CNS) tissue. Discrimination among these three tissue types is possible due to variations in composition. Spectra of white matter exhibit strong lipid absorptions. In contrast, spectra of grey matter reveal a reduced lipid contribution and a significant absorption from water. MS plaques exhibit spectra indicative of lipid loss and, depending upon whether the plaques are chronic or acute, changes in the protein and/or water content.

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Lin-P'ing Choo, Michael Jackson, William C. Halliday, and Henry H. Mantsch "Infrared spectroscopic characterization of human white matter, grey matter, and multiple sclerosis lesions", Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); https://doi.org/10.1117/12.166686

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