LDF assessment of tumor blood flow and flux motions in photodynamic therapy

Valentine I. Kozlov; Oleg Alexandrov Terman

doi:10.1117/12.273612

2 May 1997 LDF assessment of tumor blood flow and flux motions in photodynamic therapy

Valentine I. Kozlov, Oleg Alexandrov Terman

Proceedings Volume 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology; (1997) https://doi.org/10.1117/12.273612
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

In patients with basal cell carcinoma (BCC) skin microcirculation was measured by the laser Doppler flowmeter (LDF). Spectral analysis of LDF-signal based on fast Fourier transform enables us to evaluate an amplitude and predominated frequency of flux motions in the next diapasons: (alpha) -rhythm, (beta) -rhythm, (gamma) -rhythm, high-frequency rhythm and cardiorhythm. For photodynamic therapy (PDT) hematoporphyrin derivative was administrated intravenously in dosage 1-2 mg/Kg. In 24 hours after that all patients were exposed to the red laser irradiation in dose 200-300 J/cm². The microcirculation level in BCC was higher than in the plots of healthy skin. Exactly after PDT the marked decrease of microcirculation up to 4.7 +/- 0.63 a.u. associated with photoinduced stasis took place in the tumor. Spectral analysis of flux motions demonstrated a significant inhibition of (alpha) -, (beta) -rhythms and amplification of HF- and CF-rhythm In 1 week after PDT we observed a gradual restoration of microcirculation in the zone of PDT skin injury that followed a wound healing process.

Citation Download Citation

Valentine I. Kozlov and Oleg Alexandrov Terman "LDF assessment of tumor blood flow and flux motions in photodynamic therapy", Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); https://doi.org/10.1117/12.273612

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available