POPC, DPPC/DMPC and POPC/OOPS liposomes containing gadolinium(III) meso-tetraphenylporphyrin and gadolinium(III) meso-tetra(4-pyridyl)porphyrin have been prepared by different techniques, their porphyrin and lipid contents have been evaluated, and the size and stability of the liposomes have been determined. The results show the influence of the method of preparation on the amount of Gd-porphyrin incorporated, and that of the lipid composition on the incorporation efficiency and stability of the Gd(III) porphyrin trapped in the liposomes, as well as the presence of strong lipid to porphyrin association at least in the case of the DPPC/DMPC liposomes.
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