Photodynamic therapy for breast cancer with photosense

Elena G. Vakoulovskaya M.D.; Victor V. Shental M.D.; Yury V. Buidenok; Georgui I. Solomakho; Tatiana M. Nadezhdina

doi:10.1117/12.424433

9 April 2001 Photodynamic therapy for breast cancer with photosense

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., Yury V. Buidenok, Georgui I. Solomakho, Tatiana M. Nadezhdina

Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424433
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Photodynamic Therapy (PDT) using second-generation photosensitizer Aluminium Phtalocyanine (NIOPIC, Russia) (PS) in dose 0.5-0.8 mg per kg of body weight have been provided in 15 patients with breast cancer. In 5 patients with T2-T3NOMO primary tumor was treated as the preoperarive treatment, radical mastectomy has been fulfilled after PDT with subsequent histological examination. 10 patients had local recurrencies of breast cancer after combined treatment, chemotherapy and radiotherapy. Fluorescent diagnostics of tumor, accumulation of PS in tumor, adjacent tissue before and during PDT was fulfilled. For PDT semiconductive laser -X=672+2nm, P=1,5 W was used. Treating primary tumor interstitial irradiation has been done in light dose l5OJIcm3. In patients with skin metastases multiple surface irradiations were provided with interval 24-72 hours and total light dose 400-900 J/cm2. In cases of preoperative PDT pathomorphosis of different degree has been found in all cases. In patients with advanced skin recurrencies of breast cancer partial regression of tumor has been got in 2 monthes after PDT or progression with lung or bone metastasis. In 5patients with early skin metastases in 80% complete responce've been got 2 monthes after treatment with recurrencies in 6 monthes in 60% patients. Our experience show pronounced efficacy of PDT for treating breast cancer.

Citation Download Citation

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., Yury V. Buidenok, Georgui I. Solomakho, and Tatiana M. Nadezhdina "Photodynamic therapy for breast cancer with photosense", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); https://doi.org/10.1117/12.424433

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