Transient grating of laser-induced 1 Deltag O2 production by photodynamic therapy agents

Andrew C. Beveridge; Barbara A. Bench; Irio G. Calasso; Sergiu M. Gorun; Gerald J. Diebold

doi:10.1117/12.429304

15 June 2001 Transient grating of laser-induced ¹Δ_gO₂ production by photodynamic therapy agents

Andrew C. Beveridge, Barbara A. Bench, Irio G. Calasso, Sergiu M. Gorun, Gerald J. Diebold

Proceedings Volume 4256, Biomedical Optoacoustics II; (2001) https://doi.org/10.1117/12.429304
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The transient grating method acts as a monitor of the evolution of thermal energy following optical excitation of an absorbing molecule. The signals produced by a photodynamic therapy agent are shown to be strongly dependent on presence of oxygen in solution indicating transfer of energy from a triplet state of the dye to form excited ¹Δ_g oxygen. Analysis of the data shows that the efficiency of excited oxygen production can be determined by a recording of the diffracted light intensity versus time.

Citation Download Citation

Andrew C. Beveridge, Barbara A. Bench, Irio G. Calasso, Sergiu M. Gorun, and Gerald J. Diebold "Transient grating of laser-induced ¹Δ_gO₂ production by photodynamic therapy agents", Proc. SPIE 4256, Biomedical Optoacoustics II, (15 June 2001); https://doi.org/10.1117/12.429304

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