Clinical and histological evaluation of wound healing in the paranasal sinus mucosa following neodymium:YAG laser therapy

Justus F. R. Ilgner M.D.; Oliver Emmerling M.D.; Stefan Biesterfeld M.D.; Martin Westhofen M.D.

doi:10.1117/12.430667

17 June 2002 Clinical and histological evaluation of wound healing in the paranasal sinus mucosa following neodymium:YAG laser therapy

Justus F. R. Ilgner M.D., Oliver Emmerling M.D., Stefan Biesterfeld M.D., Martin Westhofen M.D.

Author Affiliations +

Proceedings Volume 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII; (2002) https://doi.org/10.1117/12.430667
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Laser surgery has been proven a valuable tool in treating recurrent chronic-polypous sinusitis when conservative treatment is ineffective. As thermic ablation is one of the key principles, the question remains whether wound healing in the mucosa is prolonged or results in superficial scarring. After 143 Neodymium:YAG laser procedures for the ablation of recurrent polyps under local anesthesia, 14 biopsies were taken during an interval of 6 days to 2 years from the laser-treated mucosa. All were examined histologically. 16 biopsies were taken from patients after conventional endonasal microscopic sinus surgery. All patients had been followed up by regular endoscop employing a combined anti-inflammatory, anti-allergic drug regime. In the laser-treated group, 5 of 14 cases showed a prolonged inflammatory reaction including submucosal edema, granulocyte infiltration for up to 3 to 4 months, while the control group tended to show submucosal lymphocyte infiltration and formation of collagenous tissue in 6 of 16 cases. The interval of 8 months average, which eventually leads to restitution of respiratory epithelium, is the same in both groups. While wound healing is comparable to conventional surgery, laser surgery has the advantage of being a minimally-invasive out-patient procedure, which helps to avoid extensive conventional revision surgery.

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Justus F. R. Ilgner M.D., Oliver Emmerling M.D., Stefan Biesterfeld M.D., and Martin Westhofen M.D. "Clinical and histological evaluation of wound healing in the paranasal sinus mucosa following neodymium:YAG laser therapy", Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); https://doi.org/10.1117/12.430667

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KEYWORDS

Laser therapeutics

Surgery

Wound healing

Nd:YAG lasers

Tissues

Laser vision correction

Laser tissue interaction

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