Photodynamic therapy on the ultrastructure of glioma cell

Shaoshan Hu; Ruyou Zhang; Yongri Zheng

doi:10.1117/12.639223

11 September 2006 Photodynamic therapy on the ultrastructure of glioma cell

Shaoshan Hu, Ruyou Zhang, Yongri Zheng

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 59670Y (2006) https://doi.org/10.1117/12.639223
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

OBJECTIVE: the main purpose of this experiment was to study the change of C6 glioma cells' ultrastructure treated by photodynamic therapy (PDT), observe the change of morphology METHOD: Make the model of rat glioma by transplanted C6 glioma cells into caudate nucleus, treated the glioma rat by PDT after two weeks. Observed the difference of subcellular structure before and after PDT by electron microscope. RESULT: Apoptosis and necrosis can be seen after treated by PDT in the C6 glioma, basal membrance damaged, number of cellular organ of endothelial cell of blood capillary declined, tight junction of endothelial cell lengthen and the gap enlarge. The PDT has slightly effect on the nomorl rat's subcellular structue. CONCLUSION: PDT can induce the apoptosis and necrosis of C6 glioma cell. The damage of the ultramicrostructure of mitochondria and endoplasmic reticulum was the foundmentol of the change. PDT initiate the damage of BBB of the C6 glioma cell and weeken the function, and makes it a useful way of treating the glioma combined with chemotherapy.

Citation Download Citation

Shaoshan Hu, Ruyou Zhang, and Yongri Zheng "Photodynamic therapy on the ultrastructure of glioma cell", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59670Y (11 September 2006); https://doi.org/10.1117/12.639223

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