Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing

Melissa A. Lapierre-Devlin; Shana O. Kelley

doi:10.1117/12.630723

11 November 2005 Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing

Melissa A. Lapierre-Devlin, Shana O. Kelley

Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 600705 (2005) https://doi.org/10.1117/12.630723
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

Three-dimensional gold nanowire ensembles (NEE) are a novel and useful platform for electrochemical DNA detection. Work performed in our laboratory using the three-dimensional nanostructures with an electrocatalytic reporter system has produced attomole sensitivity towards target DNA sequences. Large electrocatalytic signals observed at DNA-modified nanowires produce high signal-to-noise ratios, which is one factor that contributes to the improved sensitivity. DNA- modified nanostructures generate amplified electrocatalysis signals that are significantly larger than those observed at bulk gold surfaces, and our experiments indicate that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion and accessibility occurring around these structures. The heightened sensitivity achieved indicates that the nanowire ensembles constitute a promising platform for ultrasensitive biosensors.

Citation Download Citation

Melissa A. Lapierre-Devlin and Shana O. Kelley "Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 600705 (11 November 2005); https://doi.org/10.1117/12.630723

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available