Time-domain terahertz spectroscopy of artificial skin

Peter M. Corridon; Ricardo Ascázubi; Courtney Krest; Ingrid Wilke

doi:10.1117/12.646632

25 February 2006 Time-domain terahertz spectroscopy of artificial skin

Peter M. Corridon, Ricardo Ascázubi, Courtney Krest, Ingrid Wilke

Proceedings Volume 6080, Advanced Biomedical and Clinical Diagnostic Systems IV; 608007 (2006) https://doi.org/10.1117/12.646632
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Time-domain Terahertz (THz) spectroscopy and imaging is currently evaluated as a novel tool for medical imaging and diagnostics. The application of THz-pulse imaging of human skin tissues and related cancers has been demonstrated recently in-vitro and in-vivo. With this in mind, we present a time-domain THz-transmission study of artificial skin. The skin samples consist of a monolayer of porous matrix of fibers of cross-linked bovine tendon collagen and a glycosaminoglycan (chondroitin-6-sulfate) that is manufactured with a controlled porosity and defined degradation rate. Another set of samples consists of the collagen monolayer covered with a silicone layer. We have measured the THz-transmission and determined the index of refraction and absorption of our samples between 0.1 and 3 THz for various states of hydration in distilled water and saline solutions. The transmission of the THz-radiation through the artificial skin samples is modeled by electromagnetic wave theory. Moreover, the THz-optical properties of the artificial skin layers are compared to the THz-optical properties of freshly excised human skin samples. Based on this comparison the potential use of artificial skin samples as photo-medical phantoms for human skin is discussed.

Citation Download Citation

Peter M. Corridon, Ricardo Ascázubi, Courtney Krest, and Ingrid Wilke "Time-domain terahertz spectroscopy of artificial skin", Proc. SPIE 6080, Advanced Biomedical and Clinical Diagnostic Systems IV, 608007 (25 February 2006); https://doi.org/10.1117/12.646632

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available