Noninvasive blood glucose monitoring with laser diode

Xiqin Zhang; Jianhong Chen; Ean Tat Ooi; Joon Hock Yeo

doi:10.1117/12.642177

27 February 2006 Noninvasive blood glucose monitoring with laser diode

Xiqin Zhang, Jianhong Chen, Ean Tat Ooi, Joon Hock Yeo

Proceedings Volume 6094, Optical Diagnostics and Sensing VI; 60940H (2006) https://doi.org/10.1117/12.642177
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The non-invasive measurement of blood sugar level was studied by use of near infrared laser diodes. The in vitro and in vivo experiments were carried out using six laser diodes having wavelengths range from 1550 nm to 1750nm. Several volunteers were tested for OGTT (Oral Glucose Tolerance Test) experiment. We took blood from a fingertip and measured its concentration with a glucose meter while taking signal voltage from laser diodes system. The data of signal voltage were processed to do calibration and prediction; in this paper PLS (Partial Least Square) method was used to do modeling. For in vitro experiment, good linear relationship between predicted glucose concentration and real glucose concentration was obtained. For in vivo experiments, we got the blood sugar level distributions in Clarke error grid that is a reference for doctors to do diagnosis and treatment. In the Clarke error grid, 75% of all data was in area A and 25 % was in area B. From the in vitro and in vivo results we know that multiple laser diodes are suitable for non-invasive blood glucose monitoring.

Citation Download Citation

Xiqin Zhang, Jianhong Chen, Ean Tat Ooi, and Joon Hock Yeo "Noninvasive blood glucose monitoring with laser diode", Proc. SPIE 6094, Optical Diagnostics and Sensing VI, 60940H (27 February 2006); https://doi.org/10.1117/12.642177

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