Quantitative determination of glucose concentration by swept-source spectral interferometry and spectral phase analysis

Sanghoon Oh; Kirill V. Larin; Thomas E. Milner

doi:10.1117/12.702315

13 February 2007 Quantitative determination of glucose concentration by swept-source spectral interferometry and spectral phase analysis

Sanghoon Oh, Kirill V. Larin, Thomas E. Milner

Author Affiliations +

Proceedings Volume 6430, Advanced Biomedical and Clinical Diagnostic Systems V; 64301W (2007) https://doi.org/10.1117/12.702315
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We report results of a study demonstrating that swept-source spectral interferometry and spectral phase analysis may be applied to determine quantitatively the concentration of glucose in aqueous solutions. The optical system incorporates a frequency swept laser and fiber-based common-path interferometer and provides a compact, stable experimental system. Spectral phase analysis includes a fast Lomb-Scargle algorithm and a multitaper spectral estimation method that allows for time-frequency analysis. The results show highly sensitive and accurate determination of glucose concentration in solutions with 0.54 mM of resolution and 0.999 correlation coefficient. Swept-source spectral interferometry with spectral phase analysis is a promising methodology for further development of a convenient glucose-sensing method with superior sensitive and accuracy.

Citation Download Citation

Sanghoon Oh, Kirill V. Larin, and Thomas E. Milner "Quantitative determination of glucose concentration by swept-source spectral interferometry and spectral phase analysis", Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301W (13 February 2007); https://doi.org/10.1117/12.702315

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