Self-calibrated dynamical optical biochip system using surface plasmon resonance imaging: application to genotyping

Jérôme Hottin; Julien Moreau; Jolanda Spadavecchia; Alain Bellemain; Laure Lecerf; Michel Goossens; Michael Canva

doi:10.1117/12.781364

9 May 2008 Self-calibrated dynamical optical biochip system using surface plasmon resonance imaging: application to genotyping

Jérôme Hottin, Julien Moreau, Jolanda Spadavecchia, Alain Bellemain, Laure Lecerf, Michel Goossens, Michael Canva

Author Affiliations +

Proceedings Volume 6991, Biophotonics: Photonic Solutions for Better Health Care; 69910Q (2008) https://doi.org/10.1117/12.781364
Event: SPIE Photonics Europe, 2008, Strasbourg, France

Abstract

The present paper summarizes some of our work in the field of genetic diagnosis using Surface Plasmon Resonance Imaging. The optical setup and its capability are presented, as well as the gold surface functionalization used. Results obtained with oligonucleotides targets, specific to Cystic Fibrosis disease, in high and low concentration are shown. The self-calibration method we have developed to reduce data dispersion in genetic diagnosis applications is described.

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Jérôme Hottin, Julien Moreau, Jolanda Spadavecchia, Alain Bellemain, Laure Lecerf, Michel Goossens, and Michael Canva "Self-calibrated dynamical optical biochip system using surface plasmon resonance imaging: application to genotyping", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 69910Q (9 May 2008); https://doi.org/10.1117/12.781364

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