Portable minimally invasive human glucose detection instrument by surface plasmon resonance

Dachao Li; Peng Wu; Jingxin Zhang; Wenshuai Liang; Kexin Xu

doi:10.1117/12.886346

28 December 2010 Portable minimally invasive human glucose detection instrument by surface plasmon resonance

Dachao Li, Peng Wu, Jingxin Zhang, Wenshuai Liang, Kexin Xu

Proceedings Volume 7544, Sixth International Symposium on Precision Engineering Measurements and Instrumentation; 754420 (2010) https://doi.org/10.1117/12.886346
Event: Sixth International Symposium on Precision Engineering Measurements and Instrumentation, 2010, Hangzhou, China

Abstract

With the improvement of living standard, the incidence of diabetes increases year by year. Minimally invasive blood glucose monitoring is an effectively way to control diabetes, and it is achieved by measuring the glucose concentration of interstitial fluid in human body. This paper presents a portable minimally-invasive human glucose detection instrument which is based on a miniature integrated surface plasmon resonance (SPR) sensor. D-galactose/D-glucose Binding Protein (GGBP) which can specifically absorb glucose moleculars is used to modify the gold surface of SPR sensor for higher sensitivity and stability. The instrument includes an interstitial fluid extraction unit, a liquid flow unit, a SPR sensor unit and a circuit control unit. Interstitial fluid is extracted from human body using the interstitial fluid extraction unit, and it is then transported to the SPR sensor by the liquid flow unit, and the SPR sensor can detect the glucose concentration in the interstitial fluid. The acquisition and process of data is controlled by the circuit control unit, which controls the operation of the whole system as well. The glucose detection resolution could reach 6.25mg/L, and the experiment result has good linearity when the glucose concentration ranges from 6.25mg/L to 50mg/L.

Citation Download Citation

Dachao Li, Peng Wu, Jingxin Zhang, Wenshuai Liang, and Kexin Xu "Portable minimally invasive human glucose detection instrument by surface plasmon resonance", Proc. SPIE 7544, Sixth International Symposium on Precision Engineering Measurements and Instrumentation, 754420 (28 December 2010); https://doi.org/10.1117/12.886346

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