Validation study toward measuring the mechanical properties of blood clots using resonant acoustic spectroscopy with optical vibrometry

Gongting Wu; Alisa S. Wolberg; Amy L. Oldenburg

doi:10.1117/12.906956

28 February 2012 Validation study toward measuring the mechanical properties of blood clots using resonant acoustic spectroscopy with optical vibrometry

Gongting Wu, Alisa S. Wolberg, Amy L. Oldenburg

Author Affiliations +

Proceedings Volume 8214, Advanced Biomedical and Clinical Diagnostic Systems X; 82140G (2012) https://doi.org/10.1117/12.906956
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Clot elastic modulus (CEM) has recently been shown to correlate with various hemostatic and thrombotic disorders and may be an important diagnostic parameter in cardiovascular diseases. Current methods of CEM measurement lack repeatability and require large sample volume. We present a novel method named resonant acoustic spectroscopy with optical vibrometry (RASOV) that has the potential to assess CEM with higher accuracy and speed, and lower sample volume. To validate RASOV, we measured the acoustic spectrum of agarose gel with varied concentrations in openfaced rectangular wells. Results showed a linear relationship between the natural resonant frequency and agarose content within a concentration range of 4 to 12 mg/mL. Furthermore, we observed that the resonant frequencies decrease with increasing transducer mass. As a highly accurate, resonance-based method, RASOV has great potential for biomechanical properties measurement, especially for human blood.

Citation Download Citation

Gongting Wu, Alisa S. Wolberg, and Amy L. Oldenburg "Validation study toward measuring the mechanical properties of blood clots using resonant acoustic spectroscopy with optical vibrometry", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 82140G (28 February 2012); https://doi.org/10.1117/12.906956

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