Simulation of the dependence of spatial fluence profiles on tissue optical properties

S. Miller; K. Mitra

doi:10.1117/12.2213841

7 March 2016 Simulation of the dependence of spatial fluence profiles on tissue optical properties

S. Miller, K. Mitra

Proceedings Volume 9706, Optical Interactions with Tissue and Cells XXVII; 97061Q (2016) https://doi.org/10.1117/12.2213841
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Medical laser applications are promoted as safe, effective treatments for a multiplicity of concerns, ranging from hyperthermal skin rejuvenation to subcutaneous tumor ablation. Chromophore and structural protein concentration and distribution within a patient’s tissue vary from patient to patient and dictate the interaction of incident radiative energy of a specific wavelength with the target tissue. Laser parameters must be matched to tissue optical and thermal properties in order to achieve the desired therapeutic results without inducing unnecessary tissue damage, although accurate tissue optical properties are not always measured prior to and during laser therapies. A weighted variable step size Monte Carlo simulation of laser irradiation of skin tissue was used to determine the effects of variations in absorption (μ_a) and scattering coefficients (μs) and the degree of anisotropy (g) on the radiant energy transport per mm² in response to steady-state photon propagation. The three parameters were varied in a factorial experimental design for the ranges of 0.25/mm ≤ μ_a ≤ 2.0/mm, 30.0/mm ≤ μ_s ≤ 140.0/mm, and 0.65 ≤ g ≤ 0.99 in order to isolate their impacts on the overall fluence distribution. Box plots of the resulting fluence profiles were created and compared to identify ranges in which optical property variance could be considered to significantly impact the spatial variance of fluence within the simulation volume. Results indicated that accurate prediction of the fluence profiles that will be achieved by any given medical laser treatment is unlikely without pre-treatment assessment of the tissue optical properties of individual patients.

Citation Download Citation

S. Miller and K. Mitra "Simulation of the dependence of spatial fluence profiles on tissue optical properties", Proc. SPIE 9706, Optical Interactions with Tissue and Cells XXVII, 97061Q (7 March 2016); https://doi.org/10.1117/12.2213841

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available