Cannabis agonist injection effect on the coupling architecture in cortex of WAG/Rij rats during absence seizures

Marina V. Sysoeva; Galina D. Kuznetsova; Clementina M. van Rijn; Ilya V. Sysoev

doi:10.1117/12.2225578

21 April 2016 Cannabis agonist injection effect on the coupling architecture in cortex of WAG/Rij rats during absence seizures

Marina V. Sysoeva, Galina D. Kuznetsova, Clementina M. van Rijn, Ilya V. Sysoev

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Proceedings Volume 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS); 99171X (2016) https://doi.org/10.1117/12.2225578
Event: Saratov Fall Meeting 2015, 2015, Saratov, Russian Federation

Abstract

WAG/Rij rats are well known genetic model of absence epilepsy, which is traditionally considered as a nonconvulsive generalised epilepsy of unknown aetiology. In current study the effect of (R)-(+)-WIN 55,212-2 (cannabis agonist) injection on the coupling between different parts of cortex was studied on 27 male 8 month old rats using local field potentials. Recently developed non-linear adapted Granger causality approach was used as a primary method.

It was shown that first 2 hours after the injection the coupling between most channel pairs rises in comparison with the spontaneous activity, whilst long after the injection (2-6 hours) it drops down. The coupling increase corresponds to the mentioned before treatment effect, when the number and the longitude of seizures significantly decreases. However the subsequent decrease of the coupling in the cortex is accompanied by the dramatic increase of the longitude and the number of seizures. This assumes the hypothesis that a relatively higher coupling in the cortical network can prevent the seizure propagation and generalisation.

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Marina V. Sysoeva, Galina D. Kuznetsova, Clementina M. van Rijn, and Ilya V. Sysoev "Cannabis agonist injection effect on the coupling architecture in cortex of WAG/Rij rats during absence seizures", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171X (21 April 2016); https://doi.org/10.1117/12.2225578

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KEYWORDS

Epilepsy

Electrodes

Genetics

Brain

Thalamus

Electroencephalography

Electroluminescent displays

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