Multiwavelength laser doppler holography (MLDH) for human retinal blood flow visualization and quantification in vivo

Dawid Borycki; Egidijus Auksorius; Piotr Węgrzyn; Kamil Liżewski; Sławomir Tomczewski; Ieva Žičkienė; Karolis Adomavičius; Maciej Wojtkowski

doi:10.1117/12.2612568

7 March 2022 Multiwavelength laser doppler holography (MLDH) for human retinal blood flow visualization and quantification in vivo

Dawid Borycki, Egidijus Auksorius, Piotr Węgrzyn, Kamil Liżewski, Sławomir Tomczewski, Ieva Žičkienė, Karolis Adomavičius, Maciej Wojtkowski

Author Affiliations +

Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC1194802 (2022) https://doi.org/10.1117/12.2612568
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We recently demonstrated high-speed, high-resolution structural imaging of the human eye in vivo by spatiotemporal optical coherence tomography (STOC-T). STOC-T extends the Fourier-Domain Full-Field Optical Coherence Tomography (FD-FF-OCT) by the spatial phase modulation to improve the imaging depth and suppress coherent noises. Here, we show that the dataset produced by STOC-T can be processed differently to reveal blood flow in the superficial and deep retina layers. Our method, denoted as multiwavelength LDH (MLDH) enables noninvasive visualization and quantification of the blood flow deep into the human retina at high speeds and high transverse resolution in vivo.

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Dawid Borycki, Egidijus Auksorius, Piotr Węgrzyn, Kamil Liżewski, Sławomir Tomczewski, Ieva Žičkienė, Karolis Adomavičius, and Maciej Wojtkowski "Multiwavelength laser doppler holography (MLDH) for human retinal blood flow visualization and quantification in vivo", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194802 (7 March 2022); https://doi.org/10.1117/12.2612568

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KEYWORDS

Doppler tomography

Blood circulation

In vivo imaging

Holography

Visualization

Optical coherence tomography

Angiography

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