Wearable device and methods for non-invasive measurements of tissue oxygenation

Juan Pedro Cascales Sandoval; Daniel L. Greenfield; Emmanuel Roussakis; Xiaolei Li; Avery Goss; Lilian Witthauer; Liv Kelley; Conor L. Evans

doi:10.1117/12.2609177

7 March 2022 Wearable device and methods for non-invasive measurements of tissue oxygenation

Juan Pedro Cascales Sandoval, Daniel L. Greenfield, Emmanuel Roussakis, Xiaolei Li, Avery Goss, Lilian Witthauer, Liv Kelley, Conor L. Evans

Author Affiliations +

Proceedings Volume PC11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III; PC1195603 (2022) https://doi.org/10.1117/12.2609177
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present a wireless, wearable device to measure transcutaneous partial oxygen pressure (tcpO2) non-invasively. The device, tuned to physiological range pO2, detects changes in phosphorescence lifetime and intensity of ultra-bright metalloporphyrins embedded within breathable films. We have implemented machine learning algorithms to improve the accuracy of the measurements against changes in temperature, photobleaching, inter-device/film variations, etc. Our first in human measurements reveal the devices are able to detect quick and subtle changes in tcpO2 due to local and systemic changes in blood flow of skin or deeper muscle tissue. Models to extract tissue oxygenation and oxygen consumption rate are explored.

Conference Presentation

Citation Download Citation

Juan Pedro Cascales Sandoval, Daniel L. Greenfield, Emmanuel Roussakis, Xiaolei Li, Avery Goss, Lilian Witthauer, Liv Kelley, and Conor L. Evans "Wearable device and methods for non-invasive measurements of tissue oxygenation", Proc. SPIE PC11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III, PC1195603 (7 March 2022); https://doi.org/10.1117/12.2609177

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