Paced breathing hemodynamics in healthy and cancerous breast tissue measured with a high-optode density wearable diffuse optical probe

Samuel S. Spink; Adam T. Eggebrecht; Naomi Ko; Darren M. Roblyer

doi:10.1117/12.2607388

7 March 2022 Paced breathing hemodynamics in healthy and cancerous breast tissue measured with a high-optode density wearable diffuse optical probe

Samuel S. Spink, Adam T. Eggebrecht, Naomi Ko, Darren M. Roblyer

Author Affiliations +

Proceedings Volume PC11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III; PC1195605 (2022) https://doi.org/10.1117/12.2607388
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present an update on our high optode-density continuous-wave (CW) wearable diffuse optical device for the investigation of hemodynamic responses of locally advanced breast tumors during neoadjuvant chemotherapy (NAC). The device consists of a rigid-flex substrate with 32 LEDs at two wavelengths and 16 detectors. Measurements on spatially-complex flow phantoms have validated the ability to reconstruct temporal spatial absorption contrast. Preliminary results from a healthy volunteer study (N=4 volunteers) indicate that paced breathing hemodynamics can be quantified in healthy subjects, and initial clinical measurements (N=3) suggest that these hemodynamics may reveal strong tumor contrast in some instances.

Conference Presentation

Citation Download Citation

Samuel S. Spink, Adam T. Eggebrecht, Naomi Ko, and Darren M. Roblyer "Paced breathing hemodynamics in healthy and cancerous breast tissue measured with a high-optode density wearable diffuse optical probe", Proc. SPIE PC11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III, PC1195605 (7 March 2022); https://doi.org/10.1117/12.2607388

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