Combined fluorescence and spatial frequency domain imaging to monitor photodynamic therapy dosimetry throughout treatment

Alec B. Walter; Ezekiel Haugen; E. Duco Jansen

doi:10.1117/12.2613608

7 March 2022 Combined fluorescence and spatial frequency domain imaging to monitor photodynamic therapy dosimetry throughout treatment

Alec B. Walter, Ezekiel Haugen, E. Duco Jansen

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Proceedings Volume PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology; PC1195804 (2022) https://doi.org/10.1117/12.2613608
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Current methods of photodynamic therapy dosimetry are limited in their spatial and temporal resolutions. To address this, we have designed a system that combines therapeutic illumination with both fluorescence and spatial frequency domain imaging (SFDI). Fluorescence imaging during treatment provides information on the photosensitizer distribution and photobleaching rate while SFDI allows for the approximation of fluence, oxygenation, and tissue-corrected photosensitizer concentrations, but requires the treatment be paused. To minimize these interruptions, the single snapshot of optical properties approach was used which requires only a single image frame. A prototype of the system has been built and validated using calibrated phantoms.

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Alec B. Walter, Ezekiel Haugen, and E. Duco Jansen "Combined fluorescence and spatial frequency domain imaging to monitor photodynamic therapy dosimetry throughout treatment", Proc. SPIE PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology, PC1195804 (7 March 2022); https://doi.org/10.1117/12.2613608

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KEYWORDS

Photodynamic therapy

Luminescence

Optical properties

Imaging systems

Calibration

Measurement devices

Oxygen

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