Quantifying shear and tensile anisotropy in human skin in vivo with acoustic micro-tapping OCE and polarization-sensitive OCT

Matthew O'Donnell; Ivan M. Pelivanov; Hong-Cin Liou; Peijun Tang; Maju Kuriakose; Mitchell A. Kirby; Ruikang K. Wang; Russell E. Ettinger; Tam N. Pham

doi:10.1117/12.2608864

2 March 2022 Quantifying shear and tensile anisotropy in human skin in vivo with acoustic micro-tapping OCE and polarization-sensitive OCT

Matthew O'Donnell, Ivan M. Pelivanov, Hong-Cin Liou, Peijun Tang, Maju Kuriakose, Mitchell A. Kirby, Ruikang K. Wang, Russell E. Ettinger, Tam N. Pham

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Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC1196209 (2022) https://doi.org/10.1117/12.2608864
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Reconstructive skin surgeries drive the clinical need for non-contact objective measurements of skin elasticity. Here we demonstrate that all three of skin’s elastic constants (in-plane and out-of-plane shear moduli and an additional modulus defining skin’s tensile anisotropy) and the orientation of collagen fibers in dermis can be determined from Rayleigh wave anisotropy in-plane with acoustic micro-tapping (AuT) OCE. A nearly-incompressible transverse isotropic (NITI) model was used to reconstruct skin’s moduli from OCE measurements in human forearm in vivo for five healthy volunteers. Co-registered polarization-sensitive (PS-) OCT shows that optical and mechanical axes are co-aligned at measured sites.

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Matthew O'Donnell, Ivan M. Pelivanov, Hong-Cin Liou, Peijun Tang, Maju Kuriakose, Mitchell A. Kirby, Ruikang K. Wang, Russell E. Ettinger, and Tam N. Pham "Quantifying shear and tensile anisotropy in human skin in vivo with acoustic micro-tapping OCE and polarization-sensitive OCT", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC1196209 (2 March 2022); https://doi.org/10.1117/12.2608864

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KEYWORDS

Skin

Optical coherence tomography

Anisotropy

Acoustics

In vivo imaging

Injuries

Soft tissue optics

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