Real-time precision opto-control (RPOC) of biomolecules using chemical selective optical signals

Matthew Clark; Mark Carlsen; Gil A. Gonzalez; Jesus Aldana-Mendoza; Gregory S. Eakins; Chi Zhang

doi:10.1117/12.2607404

2 March 2022 Real-time precision opto-control (RPOC) of biomolecules using chemical selective optical signals

Matthew Clark, Mark Carlsen, Gil A. Gonzalez, Jesus Aldana-Mendoza, Gregory S. Eakins, Chi Zhang

Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022; PC119730D (2022) https://doi.org/10.1117/12.2607404
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Controlling behaviors of biomolecules in living cells is a challenging task. Conventional methods such as treating cells with compounds or using genetic methods do not have spatial precision. Optical tweezers can only manual manipulation of a few targets. Laser ablation methods require pre-scanning and manual target selection. Optogenetics methods also require pre-imaging and only have precision at the single-cell level. We develop a real-time precision opto-control (RPOC) platform that can selectively and precisely control biomolecules using lasers. RPOC can automatically probe and control biomolecules in dynamic living samples with high spatial accuracy, a fast response time, and high chemical selectivity.

Conference Presentation

Citation Download Citation

Matthew Clark, Mark Carlsen, Gil A. Gonzalez, Jesus Aldana-Mendoza, Gregory S. Eakins, and Chi Zhang "Real-time precision opto-control (RPOC) of biomolecules using chemical selective optical signals", Proc. SPIE PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022, PC119730D (2 March 2022); https://doi.org/10.1117/12.2607404

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