Shining light into cellular and molecular mechanisms of cardiac function and heart diseases

Ye Chen-Izu; Leighton T. Izu

doi:10.1117/12.2658791

17 March 2023 Shining light into cellular and molecular mechanisms of cardiac function and heart diseases

Ye Chen-Izu, Leighton T. Izu

Proceedings Volume PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023; PC123550F (2023) https://doi.org/10.1117/12.2658791
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Heart function is governed by three dynamic systems that control excitation-Ca2+ signaling-contraction in cardiac muscle cells. Dysregulation of these systems lead to cardiac arrhythmias, sudden death, and heart failure. We develop and use photonics technologies to shine light deep into the cellular and molecular details to investigate these dynamic systems. We use epi-fluorescence microscopy and voltage-sensitive indicator to study electrophysiology, confocal-fluorescence imaging and Ca2+ indicator to study Ca2+ signaling system, and second harmonic generation and 2-photon fluorescence microscopy to study the Ca2+ and contraction coupling in sub-cellular microdomains. I will present our research using photonics to decipher heart disease mechanisms.

Conference Presentation

Citation Download Citation

Ye Chen-Izu and Leighton T. Izu "Shining light into cellular and molecular mechanisms of cardiac function and heart diseases", Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC123550F (17 March 2023); https://doi.org/10.1117/12.2658791

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