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17 March 2023 A portable and minimally invasive human nasal potential difference (NPD) measurement system
David O. Otuya, Kadambari Vijaykumar M.D., Sophia N. Zoghbi, Nicolas M. Dechene, Emily Ryan, Sarah L. Silva, Heather Y. Harthone, Catriona N. Grant, Steven M. Rowe M.D., Marty M Solomon, Guillermo J. Tearney M.D.
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Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC1235604 (2023) https://doi.org/10.1117/12.2650620
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Cystic fibrosis (CF) is a condition arising from a genetic disorder of the cystic fibrosis transmembrane conductance regulator (CFTR) protein traversing luminal organ epithelial lining. Nasal potential difference (NPD) measurement can be used to study CF through evaluation of CFTR channel activity. Salt-bridge-based probes in combination with calomel electrodes have been used to provide discriminative information between normal and CF patients. This setup is bulky and less convenient for use in a clinical setting. Thus, we have developed a small caliber NPD probe and validated it in 3 normal subjects, providing results consisted to those reported in literature.
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David O. Otuya, Kadambari Vijaykumar M.D., Sophia N. Zoghbi, Nicolas M. Dechene, Emily Ryan, Sarah L. Silva, Heather Y. Harthone, Catriona N. Grant, Steven M. Rowe M.D., Marty M Solomon, and Guillermo J. Tearney M.D. "A portable and minimally invasive human nasal potential difference (NPD) measurement system", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC1235604 (17 March 2023); https://doi.org/10.1117/12.2650620
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KEYWORDS
Electrodes
Bridges
Cystic fibrosis
Ion channels
Modulation
Optical coherence tomography
Proteins
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