Raman arthroscopy towards in-vivo monitoring of engineered cartilage growth

Masumeh Kazemi; Chenhao Yu; Farida Korna; Dev R. Mehrotra; Juncheng Zhang; Mark W. Grinstaff; Brian D. Snyder; Mads S. Bergholt; Michael B. Albro

doi:10.1117/12.2650236

6 March 2023 Raman arthroscopy towards in-vivo monitoring of engineered cartilage growth

Masumeh Kazemi, Chenhao Yu, Farida Korna, Dev R. Mehrotra, Juncheng Zhang, Mark W. Grinstaff, Brian D. Snyder, Mads S. Bergholt, Michael B. Albro

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Proceedings Volume PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI; PC123680L (2023) https://doi.org/10.1117/12.2650236
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cartilage tissue engineering (TE) is a promising osteoarthritis treatment strategy, whereby cellularized tissue constructs are implanted in cartilage defect sites to promote tissue repair. A significant impediment to developing effective TE strategies is a lack of in vivo diagnostic platforms to monitor engineered cartilage growth. Here, we utilize an ex vivo model system of chondrocyte-seeded tissue constructs, demonstrating the capability of a novel Raman arthroscopic-configured needle probe to monitor the composition and material properties of developing TE cartilage over time. This work supports Raman arthroscopy as a clinical tool for monitoring TE cartilage, providing objective assessments of TE platform efficacies.

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Masumeh Kazemi, Chenhao Yu, Farida Korna, Dev R. Mehrotra, Juncheng Zhang, Mark W. Grinstaff, Brian D. Snyder, Mads S. Bergholt, and Michael B. Albro "Raman arthroscopy towards in-vivo monitoring of engineered cartilage growth", Proc. SPIE PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, PC123680L (6 March 2023); https://doi.org/10.1117/12.2650236

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KEYWORDS

Cartilage

Raman spectroscopy

In vivo imaging

Tissues

Tissue engineering

Collagen

Magnetic resonance imaging

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