Combined OCT-NIRF imaging for esophageal cancer detection

Tyla Danskin; Margherita Vaselli; Johannes F. de Boer

doi:10.1117/12.2649812

6 March 2023 Combined OCT-NIRF imaging for esophageal cancer detection

Tyla Danskin, Margherita Vaselli, Johannes F. de Boer

Proceedings Volume PC12371, Multimodal Biomedical Imaging XVIII; PC1237105 (2023) https://doi.org/10.1117/12.2649812
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Esophageal cancer has a low survival rate, which is significantly improved through early detection, as well as monitoring of a common pre-cursor, Barrett’s esophagus. Optical Coherence Tomography is a low coherence interferometry technique which produces three-dimensional depth scans of tissues. OCT provides morphology but lacks in molecular specificity, and can thus be combined with targeted Near Infrared Fluorescence imaging. The viability of this dual-modality technique for use in detecting BE and esophageal cancer is assessed using topically and intravenously administered Bevacizumab in combination with an OCT-NIRF system, to produce ex vivo tissue scans, which are then histology matched.

Conference Presentation

Citation Download Citation

Tyla Danskin, Margherita Vaselli, and Johannes F. de Boer "Combined OCT-NIRF imaging for esophageal cancer detection", Proc. SPIE PC12371, Multimodal Biomedical Imaging XVIII, PC1237105 (6 March 2023); https://doi.org/10.1117/12.2649812

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