Hand-held OCT probe for transcutaneous use to assess various pathologies in real-time

Nick Iftimia; John Grimble; Gopi Maguluri; Aliana Caron; Rahul Anil Sheth; Sanjay Gupta; Amanda McWaters; Savitri Krishnamurthy M.D.

doi:10.1117/12.2649157

6 March 2023 Hand-held OCT probe for transcutaneous use to assess various pathologies in real-time

Nick Iftimia, John Grimble, Gopi Maguluri, Aliana Caron, Rahul Anil Sheth, Sanjay Gupta, Amanda McWaters, Savitri Krishnamurthy M.D.

Author Affiliations +

Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC123730C (2023) https://doi.org/10.1117/12.2649157
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Real-time assessment of tissue morphology and function is a pressing clinical need. We present a low cost OCT probe based on combined position sensor feedback, as well as a data processing algorithm that enables real-time display of tissue morphology and birefringence. The preliminary evaluation of this instrument on various biological specimens has demonstrated its capability for real-time diagnosis. Its preclinical assessment in vivo on animal models of cancer was performed at MD Anderson Cancer Center. Reliable assessment of tissue morphology and birefringence has been successfully demonstrated.

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Nick Iftimia, John Grimble, Gopi Maguluri, Aliana Caron, Rahul Anil Sheth, Sanjay Gupta, Amanda McWaters, and Savitri Krishnamurthy M.D. "Hand-held OCT probe for transcutaneous use to assess various pathologies in real-time", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730C (6 March 2023); https://doi.org/10.1117/12.2649157

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KEYWORDS

Optical coherence tomography

Pathology

Cancer

Birefringence

Data processing

In vivo imaging

Position sensors

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