Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography

Pradipta Mukherjee; Shinichi Fukuda; Donny Lukmanto; Toshiharu Yamashita; Kosuke Okada; Shuichi Makita; Ibrahim G. Abd El-Sadek; Yiheng Lim; Yoshiaki Yasuno

doi:10.1117/12.2648851

7 March 2023 Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim G. Abd El-Sadek, Yiheng Lim, Yoshiaki Yasuno

Author Affiliations +

Proceedings Volume PC12378, Dynamics and Fluctuations in Biomedical Photonics XX; PC123780B (2023) https://doi.org/10.1117/12.2648851
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present three-dimensional, label-free renal tubular metabolism imaging by functional optical coherence tomography (OCT) including dynamics imaging method so-called “logarithmic intensity variance (LIV)” and OCT angiography (OCTA). Normal mouse kidneys and obstructed kidney models were investigated ex vivo. In the normal kidney, several vertical tails of high-LIV and hyper-OCTA signals were observed in the corresponding cross-sectional images. These signals formed pipe-like structures in the en face slab average projection images. In the obstructed kidneys, such anatomical pipe-like structures disappeared and instead, a circular shell at the edge of the renal cortex region was observed in the LIV.

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Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim G. Abd El-Sadek, Yiheng Lim, and Yoshiaki Yasuno "Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography", Proc. SPIE PC12378, Dynamics and Fluctuations in Biomedical Photonics XX, PC123780B (7 March 2023); https://doi.org/10.1117/12.2648851

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