Microbiome analysis of photodynamic nasal decolonization

Caetano Padial Sabino; Craig Tipton; Cristina Romo; Sheeny Levengood; Micah Chavez; Roger C. Andersen M.D.; Nicolas Loebel

doi:10.1117/12.3025380

13 March 2024 Microbiome analysis of photodynamic nasal decolonization

Caetano Padial Sabino, Craig Tipton, Cristina Romo, Sheeny Levengood, Micah Chavez, Roger C. Andersen M.D., Nicolas Loebel

Author Affiliations +

Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220E (2024) https://doi.org/10.1117/12.3025380
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photodynamic nasal decolonization is a prophylactic technology utilizing a photosensitizer activated by light to induce photochemical reactions, which rapidly and effectively eliminate pathogens without harming human tissue. Eliminating nasal-borne pathogens before surgery significantly reduces risk of infection and pathogen transmission. We report an exploratory study performed in 35 healthy volunteers in which nasal microbial population responses were characterized over time, following photodynamic nasal decolonization (Steriwave®, Ondine Biomedical Inc., Vancouver, BC, Canada). Plate culture and 16s sequencing of nasal swab samples revealed a highly significant reduction in the number of viable bacterial cells and species immediately following treatment. Over time, the microbial population returned to its initial diversity level (24 hours) and quantitative number (48 hours). This is consistent with the design intent for a powerful, non-selective bactericidal modality allowing return to microbiome baseline less than 1-week post-treatment, thereby reducing the potential for long-term microbiome disturbances.

Conference Presentation

Citation Download Citation

Caetano Padial Sabino, Craig Tipton, Cristina Romo, Sheeny Levengood, Micah Chavez, Roger C. Andersen M.D., and Nicolas Loebel "Microbiome analysis of photodynamic nasal decolonization ", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220E (13 March 2024); https://doi.org/10.1117/12.3025380

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