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13 March 2024 Translational development of antimicrobial blue light for wound infection control: new therapeutic window, treatment regimen, and wearable device
Jie Hui, Wonjoon Moon, Pu-Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, Rox Anderson, Jeremy Goverman, Jeff Gelfand, Seok-Hyun Andy Yun
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Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220I (2024) https://doi.org/10.1117/12.3001119
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Antibiotic resistance has posed a grand and rising threat to the global health. Blue light, specifically 400-430 nm range, has been shown as an attractive antimicrobial alternative considering its drug/agent-free nature, broad-spectrum antimicrobial effect, and no reported resistance. However, its clinical applications have been hampered by several major bottlenecks. Here, we present our translational development towards clinical application of blue light for managing wound infections via innovations in establishing a safe, effective treatment regimen built upon bacteriostatic and long-term illumination strategy (with therapeutical window identified between minimum inhibitory irradiance, MII, and maximum permissible irradiance, MPI), a wearable LED array-based device prototype, an in vivo testbed of free-moving rats with skin wound infections, and its integration with standard wound care procedures. These concepts, devices, safety, and effectiveness have been validated in vitro, ex vivo, and in vivo. This work paves a solid yet encouraging foundation for our follow-up clinical study on contaminated/infected wounds.
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© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Jie Hui, Wonjoon Moon, Pu-Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, Rox Anderson, Jeremy Goverman, Jeff Gelfand, and Seok-Hyun Andy Yun "Translational development of antimicrobial blue light for wound infection control: new therapeutic window, treatment regimen, and wearable device", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220I (13 March 2024); https://doi.org/10.1117/12.3001119
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KEYWORDS
Skin
Windows
Control systems
Wearable devices
In vivo imaging
Biomedical applications
Light sources and illumination
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